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Spironolactone Tablets 25mg, 50mg, 100mg Oral Medications

Categories Oral Medications
Brand Name: Newlystar
Place of Origin: China
MOQ: Three million tablets
Payment Terms: L/C, T/T
Delivery Time: 45days
Packaging Details: 10’s/blister
Model Number: 25mg, 50mg, 100mg
Certification: GMP
Price: Negotiation
Supply Ability: One million pills per day
Product: Spironolactone Tablets
Specification: 25mg, 50mg, 100mg
Standard: BP, USP
Packing: 10’s/blister
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Spironolactone Tablets 25mg, 50mg, 100mg Oral Medications

Spironolactone Tablets 25mg, 50mg, 100mg Oral Medications

Product : Spironolactone Tablets

Specification : 25mg, 50mg, 100mg

Standard : BP, USP

Packing : 10’s/blister

Description :

Spironolactone is practically insoluble in water, soluble in alcohol, and freely soluble in benzene and in chloroform.

Inactive ingredients include calcium sulfate, corn starch, flavor, hypromellose, iron oxide, magnesium stearate, polyethylene glycol, povidone, and titanium dioxide.

Indications and Usage :

Primary hyperaldosteronism for:

Establishing the diagnosis of primary hyperaldosteronism by therapeutic trial.

Short-term preoperative treatment of patients with primary hyperaldosteronism.

Long-term maintenance therapy for patients with discrete aldosterone-producing adrenal adenomas who are judged to be poor operative risks or who decline surgery.

Long-term maintenance therapy for patients with bilateral micro or macronodular adrenal hyperplasia (idiopathic hyperaldosteronism)

Edematous conditions for patients with:Congestive heart failure,Cirrhosis of the liver accompanied by edema and/or ascites,Nephrotic syndrome,Essential hypertension,Hypokalemia,Severe heart failure (NYHA class III – IV)


Spironolactone is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics. On its own, spironolactone is only a weak diuretic, but it can be combined with other diuretics. Due to its anti-androgen effect, it can also be used to treat hirsutism, and is a common component in hormone therapy for male-to-female transgendered people. Spironolactone inhibits the effect of aldosterone by competing for intracellular aldosterone receptor in the distal tubule cells. This increases the secretion of water and sodium, while decreasing the excretion of potassium. Spironolactone has a fairly slow onset of action, taking several days to develop and similarly the effect diminishes slowly.

Mechanism of action

Spironolactone is a specific pharmacologic antagonist of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule. Spironolactone causes increased amounts of sodium and water to be excreted, while potassium is retained. Spironolactone acts both as a diuretic and as an antihypertensive drug by this mechanism. It may be given alone or with other diuretic agents which act more proximally in the renal tubule. Aldosterone interacts with a cytoplasmic mineralocorticoid receptor to enhance the expression of the Na+, K+-ATPase and the Na+ channel involved in a Na+ K+ transport in the distal tubule . Spironolactone bind to this mineralcorticoid receptor, blocking the actions of aldosterone on gene expression. Aldosterone is a hormone; its primary function is to retain sodium and excrete potassium in the kidneys.

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oral medicine


oral treatment

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