Spironolactone Tablets 25mg, 50mg, 100mg Oral Medications
Product : Spironolactone Tablets
Specification : 25mg, 50mg, 100mg
Standard : BP, USP
Packing : 10’s/blister
Spironolactone is practically insoluble in water, soluble in
alcohol, and freely soluble in benzene and in chloroform.
Inactive ingredients include calcium sulfate, corn starch, flavor,
hypromellose, iron oxide, magnesium stearate, polyethylene glycol,
povidone, and titanium dioxide.
Indications and Usage :
Primary hyperaldosteronism for:
Establishing the diagnosis of primary hyperaldosteronism by
Short-term preoperative treatment of patients with primary
Long-term maintenance therapy for patients with discrete
aldosterone-producing adrenal adenomas who are judged to be poor
operative risks or who decline surgery.
Long-term maintenance therapy for patients with bilateral micro or
macronodular adrenal hyperplasia (idiopathic hyperaldosteronism)
Edematous conditions for patients with:Congestive heart
failure,Cirrhosis of the liver accompanied by edema and/or
hypertension,Hypokalemia,Severe heart failure (NYHA class III – IV)
Spironolactone is a synthetic 17-lactone steroid which is a renal
competitive aldosterone antagonist in a class of pharmaceuticals
called potassium-sparing diuretics. On its own, spironolactone is
only a weak diuretic, but it can be combined with other diuretics.
Due to its anti-androgen effect, it can also be used to treat
hirsutism, and is a common component in hormone therapy for
male-to-female transgendered people. Spironolactone inhibits the
effect of aldosterone by competing for intracellular aldosterone
receptor in the distal tubule cells. This increases the secretion
of water and sodium, while decreasing the excretion of potassium.
Spironolactone has a fairly slow onset of action, taking several
days to develop and similarly the effect diminishes slowly.
Mechanism of action
Spironolactone is a specific pharmacologic antagonist of
aldosterone, acting primarily through competitive binding of
receptors at the aldosterone-dependent sodium-potassium exchange
site in the distal convoluted renal tubule. Spironolactone causes
increased amounts of sodium and water to be excreted, while
potassium is retained. Spironolactone acts both as a diuretic and
as an antihypertensive drug by this mechanism. It may be given
alone or with other diuretic agents which act more proximally in
the renal tubule. Aldosterone interacts with a cytoplasmic
mineralocorticoid receptor to enhance the expression of the Na+,
K+-ATPase and the Na+ channel involved in a Na+ K+ transport in the
distal tubule . Spironolactone bind to this mineralcorticoid
receptor, blocking the actions of aldosterone on gene expression.
Aldosterone is a hormone; its primary function is to retain sodium
and excrete potassium in the kidneys.