CPC 90% Purity Bovine Chondroitin Sulfate Sodium Verfied by NSF-GMP
with Drug Master File DMF
Bovine chondroitin sulfate sodium is a type of Mucopolysaccharides
extracted from bovine cartialges, with 90% purity tested by CPC
titration method. The bovine cartilages used for the production of
chondroitin sulfate sodium are from health animals used for the
human consumption. The cartilages are free of BSE/TSE, and
Veterinary health certificates are available for each shipment.
The specification of bovine chondroitin sulfate sodium 90% by CPC
|Product:||Chondroitin Sulfate sodium|
|Net Weight:||25KG/DRUM||Gross weight:||27.5KG/DRUM|
|Manufacturing Date:||2017/02/10||Expiry Date:||2019/02/09|
SPECIFICATIONS (TEST METHOD)
|Appearance||White to off-white powder||Pass|
|Identification||Infra Red Confirmed (USP197K).||Pass|
|Sodium reaction (USP191)||Positive|
|The chromatogram of the enzymatically digested sample solution as
obtained in the test for the limit of nonspecific disaccharides
shows three main peaks corresponding to △DI-4S, △DI-6S,△DI-OS in
the enzymatically digested standard solution. By peak area
response, △ DI-4S is the most abundant, followed by the △ DI-6S,
with △ DI-OS being the least abundant of the three|
|Assay(ODB)||NLT90% (CPC Titration)||91.6%|
|Loss on drying||Less than12%(USP731)||8.0%|
|Heavy Metal||NMT20PPM (Method I USP231)||Pass|
|PH (1%H2O solution)||5.5-7.5(USP791)||6.4|
|Specific Rotation||- 20°~ -30°(USP781S)||-22.5°|
|Residue on Ignition||20%-30%(dry base)(USP281)||25.5%|
|OrganicVolatile Residual(Ethanol)||NMT0.5% (USP467)||PASS|
|Clarity (5%H2O solution)||<0.35@420nm||0.22|
|Bulk Density||NLT 0.5g/ml||Pass|
|Total Bacteria Count||<1000CFU/g (USP2021)||Pass|
|Yeast & Mold||<100CFU/g (USP2021)||Pass|
|Staphylococcus Aureus||Negative (USP2022)||Negative|
|Enterobacteria||Negative in 1 gram (USP2022)||Negative|
|Particle size||100% through 80 mesh||Pass|
|Storage: 25kg/drum, keep in an airtight container, protected from
The benefits of Bovine Chondroitin Sulfate Sodium:
Chondroitin sulfate is a type of Mucopolysaccharides which is
commonly found in the tissues of joints in both human and animals.
It is considered as the building block for the tissues of human
joints. Thus the benefits of chondroitin sulfate are :
1. Help to prevent the breakdow of cartilages in joints.
2. Help increase the fluids in the joints.
3. Relief the pain in the joints.
The application of Bovine Chondroitin Sulfate Sodium:
1. The main application of chondroitin sulfate is joint health
dietary supplements including Tablets, Capsules, and powder form.
2. Some bovine chondroitin sulfate is used to produce OTC Drugs in
some countries (USA excluded)
3. Bovine chondroitin sulfate could also be used to produce eye
drops or Cosmetics.
The Manufacturing Production Flow Chart of bovine chondroitin
Production Flow Chart of Bovine Chondroitin Sulfate
Pre-treatment(cartilages selecting and washing)
Boiling ( add NACL,boil for 5 hours at the temperature of 90℃)
Enzymolysis (add pancreatin, add NAOH to adjust the PH value to 8.5-9.0, boil
for 6 hours at the temperature of 48℃-50℃
First sedimentation(add ethanol to dissolve out the crude chondroitin sulfate)
Hydrolysis (add water and NACL,add NAOH to adjust PH value to about 9.0. Adjust
temperature to 48℃-50℃
Second sedimentation(add ethanol to dissolve out purified chondroitin sulfate
Dehydration (add ethanol to dehydrate the water out of chondroitin sulfate
Centrifugation (get rid of ethanol)
Milling and Sifting
Blending (No other materials are added, just mixing)
Packing and testing
Chondroitin sulfate in 25KGS/drum
The packing and Storage:
1. The packing is 25KG chondroitin sulfate is packed into Double PE
bags and put into a fiber drum.
2. The chondroitin sulfate is extremely hygroscopic, avoid exposure
to the air when unpacked the original package.
3. Packged into air tight PE bags,put into a fiber drum and then
the drum in a cool and dry place, avoid direct sunshine exposure.