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White Crystalline Pharmaceutical Raw Steroid Powder Estriol CAS 50-27-1 For Treatment Of Female Hormone

Categories Pharmaceutical Raw Materials
Brand Name: TINGYI
Model Number: CAS: 50-27-1
Certification: GMP , ISO 9001:2008
Place of Origin: CHINA
MOQ: 10g
Price: Contact Us
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 3000KG/Month
Delivery Time: Usually within 7 work days
Packaging Details: Stealth and discreet packaging
Product Name: Estriol
CAS: 50-27-1
MF: C18H24O3
MW: 288.39
Assay: 99%
appearance: White crystalline powder
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White Crystalline Pharmaceutical Raw Steroid Powder Estriol CAS 50-27-1 For Treatment Of Female Hormone

Product Name: Estriol


Product Details:



Product Name


Estriol

CAS


50-27-1

MF


C18H24O3

Molecular Weight


288.39

EINECS


200-022-2

ensity


1.255 g/cm3

Melting Point


280-282 °C(lit.)

Boiling Point


469 °C at 760 mmHg

lash Point


220.8 °C

Appearance


White crystalline powder

Assay


99%

Storage


as per relevent regulations
Usage

pharmaceutical intermediates


Description:


Estriol belongs to natural hormone and is the metabolite of estradiol in vivo , anti estrogen steroids . It is mainly presented in the urine . Estrogen has a relative small activity with the oral activity being 6 times as high as estrone but being weaker than estradiol with non-carcinogenic effects . After its administration , the in vivo estradiol levels did not change . Estriol has selective action on the vaginal and cervical canal but has no effect on the uterus and endometrium entity .
Estriol,Animal experiments have shown that estriol has a stronger effect on vaginal epithelial keratosis than estradiol , thus being able to promote vaginal epithelial hyperplasia , superficial cells keratosis , mucosal angiogenesis and vaginal epithelial wound healing , but having a weak effect on the weight gain of mouse uterus At the same time , estriol can enhance the function of cervix cell , causing the cervix muscle fiber hyperplasia and increasing the cervical elasticity and softness . In addition , estriol has feedback inhibition on the hypothalamus and pituitary but does not inhibit ovulation while only having significant impact on the corpus luteum and therefore can be used as the auxiliary drug in the medium-term labor induction and artificial abortion and for the treatment of various kinds of menopathy . Estriol also has significant effect on the hematopoietic system and can reduce vascular permeability and fragility. Therefore , it can be used for the treatment of various kinds of hemorrhage . It also has effect of rapidly increasing the peripheral leukocytes and generally begins to take effect at 1 to 3 days after treatment but with a shorter duration of action and is effective in treatment the leukopenia induced by radiotherapy and chemotherapy .


Estradiol, or more precisely, 17β-estradiol, is a human sex hormone and steroid, and the primary female sex hormone. It is named for and is important in the regulation of the estrous and menstrual female reproductive cycles. Estradiol is essential for the development and maintenance of female reproductive tissues but it also has important effects in many other tissues including bone. While estrogen levels in men are lower compared to women, estrogens have essential functions in men as well. Estradiol is found in most vertebrates as well as many crustaceans, insects, fish, and other animal species. Estradiol or oestradiol (American or British English usages), derives from estra-, Gk. οστρο? (oistros, literally meaning "verve or inspiration") and -diol, a chemical name and suffix indicating that this form of steroid and sex hormone is a type of alcohol bearing two hydroxyl groups.
Estradiol is produced especially within the follicles of female ovaries, but also in other endocrine (i.e., hormone-producing) and non-endocrine tissues (e.g., including fat, liver, adrenal, breast, and neural tissues). Estradiol is biosynthesized from progesterone (arrived at in two steps from cholesterol, via intermediate pregnenolone). One principle pathway then converts progesterone to its 17-hydroxy-derivative, and then to androstenedione via sequential cytochrome P450-catalyzed oxidations.Action of aromatase on this dione generates estrone, and action of a dehydrogenase on this gives the title compound, 17β-estradiol.



COA:


ITEMSPECIFICATIONRESULT
CharacterWhite or almost white crystalline powderWhite crystalline powder
Specific rotation+54to +62+59.9
Completeness of solutionClear and free from undissolved solidConforms
Identification(1) complies by IR
(2) complies by UV
Conforms
Conforms
Residue on IgnitionNot more than 0.1%0.05%
Loss on dryingNot more than 0.50.1%
Chromatographic
purity
Total impurities not more than 2.0%<2.0%
AssayIt should contain 97.0% to 102.0% of C18H24O3 calculated on dried basis98.4%
Particle sizeIt should be 90% below 30mConforms
ConclusionConforms to USP36

Application:


It can be used for treating cervicitis and especially suitable for treating menopausal syndrome and senile vaginitis.
It can also be used as the adjuvant drug for middle-term labor induction and artificial abortion.
It can also be used for treating prostatic hypertrophy and prostate cancer.
It still has a rapid role in increasing the peripheral leukocytes. It generally takes effect at 1 to 3 days after the treatment but with a short duration period. It also has efficacy in treating leukopenia caused by chemotherapy or radiotherapy.
It can be used for reducing the vascular permeability and fragility and can be used for the treatment of various kinds of hemorrhage. It also has quick hemostasis effect on menorrhagia, hysterectomy or tonsillectomy.



Indications It can be used for treating cervicitis, especially suitable for treating menopausal syndrome and senile vaginitis. It can also be used as the adjuvant drug for middle-term labor induction and artificial abortion. It can also be used for treating prostatic hypertrophy and prostate cancer. In addition, it still has a rapid role in increasing the peripheral leukocytes. It generally takes effect at 1 to 3 days after the treatment but with a short duration period. It also has efficacy in treating leukopenia caused by chemotherapy or radiotherapy as well as reducing the vascular permeability and fragility and can be used for the treatment of various kinds of hemorrhage. It also has quick hemostasis effect on menorrhagia, hysterectomy or tonsillectomy.

Hormonal contraception:
A chemical derivative of estradiol, ethinyl estradiol with maximum dosage 200 µg, is a major component of hormonal contraceptive devices. Combined forms of hormonal contraception contain ethinyl estradiol and a progestin, which both contribute to the inhibition of GnRH, LH, and FSH, which accounts for the ability of these birth control methods to prevent ovulation and thus prevent pregnancy. Other types of hormonal birth control contain only progestins and no ethinyl estradiol.


Hormone replacement therapy:
If severe side effects of low levels of estradiol in a woman's blood are experienced (commonly at the beginning of menopause or after oophorectomy), hormone replacement therapy may be prescribed. Such therapy is usually combined with a progestin to reduce the risk of endometrial cancer. Estrogen therapy may be used in treatment of infertility in women when there is a need to develop sperm-friendly cervical mucus or an appropriate uterine lining. This is often prescribed in combination with clomifene Estrogen therapy can also be used to treat advanced prostate cancer, as well as to relieve symptoms of breast cancer.


Hormone replacement therapy in transgender women:
Estrogen therapy is also used as part of the hormone replacement therapy for trans women. Either oral or transdermal estradiol is used in higher concentrations during initial treatment and transition; estradiol is continued in lower doses to maintain female-level hormones following gender reassignment surgery.


Blocking estrogens:
Inducing a state of hypoestrogenism may be beneficial in certain situations where estrogens are contributing to unwanted effects, e.g., certain forms of breast cancer, gynecomastia, premature closure of epiphyses, and inhibiting feminization in female-to-male transsexual hormone treatment. Estrogen levels can be reduced by inhibiting production using gonadotropin-releasing factor agonists (GnRH agonists) or blocking the aromatase enzyme using an aromatase inhibitor, or with an estrogen receptor antagonist. Estriol can be a weak or strong estrogen depending on if it is given acutely or chronically when given to immature animals, but is an antagonist when given in combination with estradiol.

Estriol may play a role in the development of breast cancer, but based on in vitro research, does appea to act as an antagonist to the G-protein coupled estrogen receptor. Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDA or Health Canada.



Functions:


Safe and Effective Hormone for Women with Hot Flashes and Vaginal Dryness
Protects Against Breast and Uterine Cancers
As a Replacement Estrogen in Breast Cancer Survivors
Prevents Vaginal Atrophy and Urinary Tract Infections
Does Not Cause Blood Clots
Protects the Skin From Aging


Our Company Advantages:


1, High quality with competitive price:

1) Standard: U.S Standard
2) All Purity≥99.8%
3) We are manufacturer and can provide high quality products with factory price.


2, Fast and safe delivery
1) Parcel can be sent out within 8 hours after payment. Tracking number available
2) Secure and discreet shipment. Various transportation methods for your choice.
3) Customs pass rate ≥99.8%
4)We provide re-ship policy.
5) We have warehouse in Australia, Canada and England, we have large amounts of stock in the warehouse, can ship to you directly from our foreign warehouse!
3, We have clients throughout the world.
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2) Meeting customers's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.


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